CRISPR-Cas9 Gene Editing for Inherited Diseases

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "rel" in aptia_page_attachments_alter() (line 649 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
Drupal\Core\DrupalKernel->handle() (Line: 19)

Warning: Undefined array key "property" in aptia_page_attachments_alter() (line 653 of themes/custom/aptia/aptia.theme).

aptia_page_attachments_alter() (Line: 458)
Drupal\Core\Theme\ThemeManager->alterForTheme() (Line: 467)
Drupal\Core\Theme\ThemeManager->alter() (Line: 320)
Drupal\Core\Render\MainContent\HtmlRenderer->invokePageAttachmentHooks() (Line: 285)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 638)
Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 286)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 128)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray()
call_user_func() (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch() (Line: 186)
Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76)
Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53)
Drupal\Core\StackMiddleware\Session->handle() (Line: 48)
Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28)
Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32)
Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 201)
Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 138)
Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 87)
Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 263)
Drupal\shield\ShieldMiddleware->bypass() (Line: 130)
Drupal\shield\ShieldMiddleware->handle() (Line: 48)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 36)
Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 51)
Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 741)
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Article

CRISPR-Cas9 Gene Editing for Inherited Diseases

Aptia

May 12, 2025

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) has revolutionized the field of gene editing, offering unprecedented precision and efficiency in modifying genomic sequences. This article provides an overview of the CRISPR-Cas9 system and its applications in the context of inherited genetic diseases. We discuss the underlying mechanisms of CRISPR-Cas9, including guide RNA design and DNA cleavage, and highlight recent advancements in enhancing its specificity and reducing off-target effects. Furthermore, we examine the preclinical and clinical studies that have employed CRISPR-Cas9 to target various inherited disorders, such as cystic fibrosis, Huntington's disease, and sickle cell anemia. The ethical considerations and challenges associated with the clinical translation of CRISPR-Cas9 technology are also addressed. This summary underscores the transformative potential of CRISPR-Cas9 in developing curative therapies for genetic diseases while acknowledging the importance of responsible innovation.

Last updated: May 15, 2025

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Combining cutting-edge technology with a team of industry experts, every aspect of pensions administration is handled with precision and care.

Solutions for your needs

Combining cutting-edge technology with a team of industry experts, every aspect of benefits administration is handled with precision and care.

Careers at Aptia

We back up our ambition with significant investment in our people.

Insights Hub

Combining cutting-edge technology with a team of industry experts, every aspect of pensions administration is handled with precision and care.

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